What question did this study set out to answer?

Examine how signals transmitted from the T lymphocyte antigen receptor control gene programs driving cell proliferation and functional exhaustion.

April 1, 1990Annual Review of Immunology

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

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Authors

KUKatharine S. UllmanUniversity of Utah JNJeffrey P. NorthropAustralian Regenerative Medicine Institute CVC L VerweijAmsterdam UMC Location Vrije Universiteit Amsterdam

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Implication

Mechanistic analysis reveals pathways linking T cell receptor signaling to exhaustion during chronic infection and cancer, highlighting key targets for restoring immune function.

Key Points

Examine how signals transmitted from the T lymphocyte antigen receptor control gene programs driving cell proliferation and functional exhaustion.
Evaluated antigen receptor signaling mechanisms responsible for activating proliferative and effector gene pathways in T lymphocytes.
Characterized phenotypic and functional changes in exhausted CD8 T cell lineages across chronic infection and tumor settings.
Identified exhausted CD8 T cells as a distinct developmental lineage defined by progressive loss of effector function.
Demonstrated that sustained upregulation of inhibitory receptors suppresses key antigen receptor signals required for immune cell proliferation.

Cite This Study

Ullman et al. (1990) studied this question.

synapsesocial.com/papers/6a7cd9e76f5e8face6febe8a https://doi.org/10.1146/annurev.iy.08.040190.002225

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Implication

Mechanistic analysis reveals pathways linking T cell receptor signaling to exhaustion during chronic infection and cancer, highlighting key targets for restoring immune function.

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

Discussion

Member takes

Implication

Key Points

Cite This Study

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

Discussion

Member takes

Implication

Key Points

Cite This Study

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