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October 1, 2025Journal of Medicine and LifeOpen Access

Tailoring BoNT A treatment and assessment across recovery stages after stroke: a report of four clinical cases

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Authors

MSMiruna Ioana SăndulescuDCDelia CintezăDRDaniel Ionuţ Răducan

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Overview

Case series reports tailored botulinum toxin A regimens improve pain and functional recovery in post-stroke spasticity, highlighting the value of stage-specific treatment.

Key Points

  • To assess the value of stage-specific, individualized botulinum toxin A dosing and functional evaluation strategies across varying severities of post-stroke spasticity.
  • Evaluated four clinical cases with post-stroke spasticity spanning Modified Ashworth Scale (MAS) grades 1+ to 4 with distinct motor control and symptom progression profiles.
  • Administered customized botulinum toxin A (BoNT-A) injections combined with conservative rehabilitation, dynamically tracking progress with case-appropriate functional scales.
  • Repeated BoNT-A injections in severe spasticity provided sustained limb pain relief and mitigated periarticular tissue damage.
  • Mild spasticity with preserved motor control achieved substantial functional recovery, allowing progressively lower BoNT-A doses and injection intervals exceeding three months.

Cite This Study

Săndulescu et al. (2025) studied this question.

synapsesocial.com/papers/6a11e52df12454ca8d21b355https://doi.org/10.25122/jml-2025-0151
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