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May 1, 1993Journal of Clinical InvestigationOpen Access

Cell-cell signaling between adult rat ventricular myocytes and cardiac microvascular endothelial cells in heterotypic primary culture.

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Population

Adult rat ventricular myocytes and cardiac microvascular endothelial cells

Comparison

Heterotypic primary culture of microvascular… vs Monocultures of microvascular endothelial cells

Design

Preclinical

Authors

MNMasashi NishidaKyoto first Red Cross hospitalJSJeremy P. SpringhornAlexion Pharma (Switzerland)RKR A KellyAstraZeneca (United Kingdom)

Discussion

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Implication

May inform cardiac remodeling models; extends in vitro observations but leaves open in vivo relevance.

Structured PICO

P
Population
Adult rat ventricular myocytes and cardiac microvascular endothelial cells
I
Intervention
Heterotypic primary culture (coculture) of microvascular endothelial cells with adult rat ventricular myocytes
C
Comparator
Monocultures of microvascular endothelial cells (with or without medium conditioned by ventricular myocytes)
O
Outcome
Appearance of preproendothelin mRNAsurrogate

Cell-cell contact between adult ventricular myocytes and microvascular endothelial cells regulates endothelial phenotype via TGF beta and endothelin signaling, suggesting dynamic reciprocal signaling in vivo.

Cite This Study

Nishida et al. (1993) studied this question.

synapsesocial.com/papers/6a11ffc20514fa642cccdbe7https://doi.org/10.1172/jci116412
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