Why the study?
Does coculture with epicardial mesothelial cells modify the phenotype and function of adult rat ventricular myocytes?
Population
Adult rat ventricular myocytes in primary culture
Comparison
Coculture with epicardial mesothelial cells vs Noncocultured myocytes or myocytes treated with…
Design
Preclinical
Authors
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Hypothesis-generating for contact-dependent myocyte plasticity; extends in vitro models but leaves clinical translation open.
Does coculture with epicardial mesothelial cells modify the phenotype and function of adult rat ventricular myocytes?
Epicardial mesothelial cells can slow or reverse the phenotypic adaptation of adult rat ventricular myocytes in culture via direct cell-cell contact, providing a useful in vitro model for studying myocyte plasticity.
Eid et al. (1992) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: