Key result
Unrecognized MI before elective PCI is linked to a ~118% higher risk of MACE.
Why the study?
Unrecognized myocardial infarction is associated with adverse outcomes, but its prevalence and prognostic significance before elective PCI remained to be elucidated.
Does the presence of unrecognized myocardial infarction detected by DE-CMR before elective PCI predict major adverse cardiac events in patients with stable coronary artery disease?
Cohort (n=213)
No
Does the presence of unrecognized myocardial infarction detected by DE-CMR before elective PCI predict major adverse cardiac events in patients with stable coronary artery disease?
Effect estimate: HR 2.18 (95% CI 1.10-4.33)
Absolute Event Rate: 27% vs 11.3%
p-value: p=0.001
Unrecognized myocardial infarction detected by DE-CMR prior to elective PCI is an independent predictor of subsequent major adverse cardiac events in patients with stable coronary artery disease.
May inform pre-PCI risk stratification in stable CAD; leaves open whether detection should guide therapy or trials.
Unrecognized myocardial infarction (UMI) is associated with adverse outcomes. This prospective, single-center study elucidated the prevalence and prognostic significance of UMI before elective percutaneous coronary intervention (PCI) using delayed-enhancement cardiac magnetic resonance (DE-CMR). We enrolled 236 patients with stable coronary artery disease who underwent DE-CMR before elective PCI. The prevalence of UMI and the association of clinical and CMR-derived variables with major adverse cardiac events (MACE), defined as cardiovascular death, nonfatal MI, hospitalization for congestive heart failure, and unplanned late revascularization, were assessed. Final analysis revealed that 63/213 (29.6%) patients had UMI. Target territory UMI was observed in 38 patients (17.8% of the total cohort, 60.3% of patients with UMI). UMI was significantly associated with sex, diabetes mellitus, left ventricular ejection fraction, SYNTAX score, and fractional flow reserve in the target vessels. During follow-up (median, 23 months), MACE occurred in 17 (27.0%) patients with UMI and 17 (11.3%) without UMI (P = 0.001). Multivariable modeling revealed that UMI (hazard ratio: 2.18, 95%CI, 1.10-4.33, P = 0.001) was an independent predictor of MACE. Kaplan-Meier analysis indicated that the presence of UMI was significantly associated with a higher incidence of MACE. UMI was independently associated with a greater risk of MACE after successful PCI.
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Nogami et al. (2022) conducted a cohort in Stable coronary artery disease (n=213). Unrecognized myocardial infarction (UMI) vs. No unrecognized myocardial infarction was evaluated on Major adverse cardiac events (MACE) (HR 2.18, 95% CI 1.10-4.33, p=0.001). Unrecognized myocardial infarction detected before elective percutaneous coronary intervention was independently associated with a greater risk of major adverse cardiac events (HR 2.18).
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