Key result
Multifactorial murine models better approximate human HFpEF than single-stressor models on clinical H2FPEF scores.
Why the study?
Development of effective HFpEF therapies is hindered by the lack of animal models adequately recapitulating human disease, with no consensus on appropriate standards for pre-clinical models.
Population
Various murine models of HFpEF
Design
Review
Authors
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May enhance translational value of HFpEF preclinical studies; leaves open systematic H2FPEF adaptation for model selection.
The H2FPEF scoring system can be adapted to systematically evaluate the clinical applicability and translational value of various rodent models of HFpEF.
Chou et al. (2022) conducted a review in Heart failure with preserved ejection fraction (HFpEF). Multifactorial murine models better approximate human heart failure with preserved ejection fraction than single-stressor models when evaluated using the clinical H2FPEF scoring system.
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