Key result
Myocardial fibrosis in patients with non-ischemic dilated cardiomyopathy was associated with significantly lower left ventricular torsion (0.62 vs 1.03 °/cm) compared to patients without fibrosis.
Why the study?
Does the presence of myocardial fibrosis affect left ventricular torsion and twist in patients with non-ischemic dilated cardiomyopathy?
Population
22 patients with non-ischemic dilated cardiomyopathy (NDC)
Comparison
Presence of myocardial fibrosis assessed by… vs Absence of myocardial fibrosis (LGE-)
Design
Cross-sectional
Authors
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Supports fibrosis-torsion link in NIDCM; hypothesis-generating, requiring prospective validation before any clinical role.
Observational (n=22)
No
Does the presence of myocardial fibrosis affect left ventricular torsion and twist in patients with non-ischemic dilated cardiomyopathy?
Absolute Event Rate: 0.62% vs 1.03%
p-value: p=0.03
In patients with non-ischemic dilated cardiomyopathy, myocardial fibrosis is associated with impaired left ventricular torsion and twist, with reversed apical systolic rotation indicating more extensive fibrosis.
Karaahmet et al. (2013) conducted an observational in Non-ischemic dilated cardiomyopathy (n=22). Myocardial fibrosis (LGE+) vs. No myocardial fibrosis (LGE-) was evaluated on Left ventricular torsion (°/cm) (p=0.03). Myocardial fibrosis in patients with non-ischemic dilated cardiomyopathy was associated with significantly lower left ventricular torsion (0.62 vs 1.03 °/cm) compared to patients without fibrosis.
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