Why the study?
Does intracoronary substance P improve left ventricular contractile performance in patients with dilated cardiomyopathy?
Population
20 patients with dilated, nonischemic cardiomyopathy
Design
Cross-sectional
Authors
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Hypothesis-generating for nitric oxide-mediated LV preload reserve in dilated cardiomyopathy; prospective trials needed before clinical translation.
Does intracoronary substance P improve left ventricular contractile performance in patients with dilated cardiomyopathy?
In patients with dilated cardiomyopathy, increased endomyocardial nitric oxide synthase expression augments LV stroke volume and stroke work via a nitric oxide-mediated increase in LV preload reserve.
Heymes et al. (1999) studied this question.
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