Why the study?
Does myocardial iNOS gene expression influence the left ventricular contractile response to beta-adrenergic stimulation in heart transplant recipients?
Population
16 heart transplant recipients free of rejection or graft vasculopathy undergoing annual coronary angiography
Comparison
Intravenous dobutamine (5 microg x kg x min) in… vs Low versus high myocardial iNOS mRNA expression
Design
Cross-sectional
Authors
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iNOS may modulate beta-adrenergic LV responses in allografts; hypothesis-generating and should not yet change practice.
Does myocardial iNOS gene expression influence the left ventricular contractile response to beta-adrenergic stimulation in heart transplant recipients?
Myocardial iNOS gene expression in human cardiac allografts influences the LV contractile response to beta-adrenergic stimulation by promoting earlier LV relaxation and reducing end-systolic pressure.
Paulus et al. (1997) studied this question.
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