Endothelial Function in Resistance and Conduit Arteries and 5-Year Risk of Cardiovascular Disease
Key result
Endothelium-dependent vasodilation in resistance arteries is linked to ~28% lower 5-year major event risk per SD.
- OR 0.72 per SD
- 95% CI 0.56 to 0.93
- P=0.01
- n=1,016
Why the study?
Little is known about the relations of endothelial function measures in resistance and conduit arteries to incident cardiovascular disease in the general population, and available techniques have not been compared.
Does endothelium-dependent vasodilation in resistance and conduit arteries predict the 5-year risk of cardiovascular disease in an elderly population?
Population
1016 participants aged 70 from the population-based PIVUS study, 52% women
Comparison
Endothelium-dependent vasodilation measured by invasive forearm technique vs brachial artery ultrasound vs pulse-wave analysis
Design
Population-based cohort study
Follow-up
5 years
Authors
Discussion
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Member takes
Implication
Endothelium-dependent vasodilation in resistance arteries, but not in the brachial conduit artery, independently predicts the 5-year risk of death, MI, or stroke in an elderly population and improves risk discrimination.
Study Design
Type
Cohort (n=1,016)
Multicenter
No
Structured PICO
Does endothelium-dependent vasodilation in resistance and conduit arteries predict the 5-year risk of cardiovascular disease in an elderly population?
P
Population
1016 participants (70 years of age) from the population-based Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, 52% women. 85 persons with a history of myocardial infarction or stroke at baseline were excluded from the outcome analysis.
I
Intervention
Measurement of endothelium-dependent vasodilation using the invasive forearm technique with acetylcholine, brachial artery ultrasound technique (flow-mediated dilatation), and pulse-wave analysis-based method with terbutaline provocation.
O
Outcome
Composite end point of myocardial infarction, stroke, or death at 5 years of follow-up.composite
Main Result
Effect estimate: OR 0.72 per SD (95% CI 0.56 to 0.93)
p-value: p=0.01
Endothelium-dependent vasodilation in resistance arteries, but not in the brachial conduit artery, independently predicts the 5-year risk of death, MI, or stroke in an elderly population and improves risk discrimination.
Cite This Study
Lind et al. (2011) conducted a cohort in Incident cardiovascular disease (n=1,016). Endothelium-dependent vasodilation measurement was evaluated on Composite of myocardial infarction, stroke, or death (OR 0.72 per SD, 95% CI 0.56 to 0.93, p=0.01). Endothelium-dependent vasodilation in resistance arteries was associated with a lower 5-year risk of death, myocardial infarction, or stroke (OR 0.72 per SD; 95% CI 0.56-0.93; P=0.01).