Key result
Higher genetically proxied SBP links to ~17% greater AF risk per 10 mm Hg.
Why the study?
Observational studies show an association between hypertension and AF, but whether hypertension is causative for AF remains unclear.
Does genetically predicted higher blood pressure increase the risk of atrial fibrillation?
Observational
Does genetically predicted higher blood pressure increase the risk of atrial fibrillation?
Effect estimate: OR 1.17 (95% CI 1.11-1.22)
p-value: p=1x10^-11
Genetically predicted higher blood pressure is associated with an increased risk of atrial fibrillation, supporting a causal relationship and suggesting potential benefit from blood pressure reduction with calcium channel blockers or beta-blockers.
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Supports BP lowering to reduce AF risk; extends causal evidence from Mendelian randomization.
Hyman et al. (2021) conducted an observational in Atrial fibrillation. Genetically proxied systolic blood pressure was evaluated on Risk of atrial fibrillation (OR 1.17, 95% CI 1.11-1.22, p=1x10^-11). A 10 mm Hg increase in genetically proxied systolic blood pressure was associated with an increased risk of atrial fibrillation (OR 1.17; 95% CI 1.11-1.22; P=1x10^-11).
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