Key result
Depressed CABG patients carrying the long (L) allele of the 5HTTLPR polymorphism were significantly more likely to have a new cardiac event within 2 years compared to S/S carriers (p=0.0002).
Why the study?
Do serotonin-related gene polymorphisms and depressive symptoms predict adverse cardiac events after CABG surgery?
Cohort (n=427)
Do serotonin-related gene polymorphisms and depressive symptoms predict adverse cardiac events after CABG surgery?
p-value: p=0.0002
The 5HTTLPR polymorphism combined with depressive symptoms identifies CABG patients at high risk for subsequent adverse cardiac events.
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May aid risk stratification in depressed CABG patients; leaves open need for prospective validation.
Li et al. (2008) conducted a cohort in Coronary artery bypass graft (CABG) surgery (n=427). Depressive symptoms and 5HTTLPR polymorphism (L allele) vs. Non-depressed patients and S/S carriers was evaluated on New cardiac event within 2 years of surgery (p=0.0002). Depressed CABG patients carrying the long (L) allele of the 5HTTLPR polymorphism were significantly more likely to have a new cardiac event within 2 years compared to S/S carriers (p=0.0002).
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