Heart failure with preserved ejection fraction was associated with similar mortality compared to reduced ejection fraction in elderly patients, with no statistically significant differences observed.
Observational (n=301)
No
Does mortality differ between elderly patients with HFPEF and HFREF?
In elderly patients, HFPEF and HFREF have similar mortality and clinical characteristics, though HFPEF is more prevalent in women and associated with hypertensive heart disease.
OBJECTIVES: The aim of this study was to assess prevalence, clinical characteristics, and prognosis in elderly patients with heart failure with preserved ejection fraction (HFPEF) compared to patients with heart failure with reduced ejection fraction (HFREF) who were followed in an internal medicine unit. METHODS: In this retrospective observational study, the sample consisted of 301 patients followed in an internal medicine referral unit between January 2007 and December 2010. All patients were checked to determine their vital status on 31 December 2012. Survival was analyzed using Kaplan-Meier curves, and compared using the log-rank test. RESULTS: Of the 301 patients, 165 (54.8%) were women. In the 263 cases (87.4%) who underwent echocardiographic assessment, 190 (72.2%) had HFPEF and 73 (27.8%) had HFREF. Mean age was similar in the two groups (80.1 and 79.9 years; p=0.905), with a predominance of women in the HFPEF group (60.5% women, 42.5% men; p=0.025). The main etiology was hypertensive heart disease in the HFPEF group. Regarding treatment, more beta-blockers were administered in the HFREF group. No statistically significant differences were observed between the groups in terms of cardiovascular risk factors, comorbidities, NYHA functional class, or mortality. CONCLUSION: Clinical characteristics were similar for both HFPEF and HFREF patients. Women were predominant in the HFPEF group, as was hypertensive etiology. No significant differences in mortality were observed between the groups.
Martínez-Braña et al. (Wed,) conducted a observational in Heart failure (n=301). Heart failure with preserved ejection fraction (HFPEF) vs. Heart failure with reduced ejection fraction (HFREF) was evaluated on Mortality. Heart failure with preserved ejection fraction was associated with similar mortality compared to reduced ejection fraction in elderly patients, with no statistically significant differences observed.