Key result
Octogenarian status is linked to over double the in-hospital heart failure mortality versus younger patients.
Why the study?
Heart failure is common in older people and associated with poor outcome, but management and outcomes in octogenarians hospitalized for heart failure are not well characterized.
How do clinical characteristics, treatment, and short-term outcomes differ between octogenarians and younger patients hospitalized for heart failure?
Comparison
Octogenarians (median age 85 years) vs younger patients (median age 69 years)
Design
Observational cohort study
Follow-up
12 weeks
Authors
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Octogenarians hospitalized for HF warrant closer GDMT scrutiny; observational data leaves open whether closing treatment gaps improves survival.
Observational (n=10,692)
Yes
How do clinical characteristics, treatment, and short-term outcomes differ between octogenarians and younger patients hospitalized for heart failure?
Absolute Event Rate: 13% vs 5%
p-value: p=<0.001
Octogenarians hospitalized for heart failure have higher mortality, more preserved ejection fraction, and are significantly less likely to receive guideline-directed medical therapies like ACE inhibitors and beta-blockers compared to younger patients.
Komajda et al. (2006) conducted an observational in Heart Failure (n=10,692). Octogenarians vs. Younger patients was evaluated on In-hospital mortality (p=<0.001). Octogenarians hospitalized for heart failure experienced higher in-hospital mortality than younger patients (13% vs. 5%, P<0.001) and were less likely to receive ACE inhibitors and beta-blockers.
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