Key result
Transgenic mice expressing a chimeric mSCARB2/hSCARB2 receptor were efficiently infected intragastrically with EV71, developing neurological symptoms and age-dependent susceptibility resembling human infection.
Why the study?
The lack of a murine oral infection model thwarted the study of pathogenesis induced by clinically relevant EV71 strains transmitted via the oral route.
A novel transgenic mouse model expressing a chimeric mSCARB2/hSCARB2 receptor successfully mimics human oral EV71 infection, providing a valuable tool for studying viral pathogenesis and evaluating vaccines or antiviral drugs.
Establishes a murine model mimicking human EV71 infection; leaves open its utility for vaccines or antivirals pending validation.
The availability of a murine model of EV71 infection is beneficial for the understanding of pathogenic mechanisms and the development and assessment of vaccines and antiviral drugs. However, the lack of a murine oral infection model thwarted the study of pathogenesis induced by clinically relevant EV71 strains that are transmitted via the oral-oral or oral-fecal route. Our Tg mice could be intragastrically infected with clinically relevant EV71 strains in an efficient way and developed neurological symptoms and pathological changes strikingly resembling those of human infection. Moreover, these mice showed an age-dependent change in susceptibility that is similar to the human case. This Tg mouse, when combined with the use of other genetically modified mice, potentially contributes to studying the relationship between developmental changes in immunity and susceptibility to virus.
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Yang et al. (2019) studied Enterovirus 71 (EV71) infection. Intragastric infection with clinically relevant EV71 strains was evaluated on Neurological symptoms and pathological changes. Transgenic mice expressing a chimeric mSCARB2/hSCARB2 receptor were efficiently infected intragastrically with EV71, developing neurological symptoms and age-dependent susceptibility resembling human infection.
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