Key result
Radiation-induced heart disease is driven by reactive oxygen species, inflammation, and endothelial dysfunction, providing potential targets for intervention to modify radiation damage progression.
Why the study?
What are the basic mechanisms and potential early markers of radiation-induced heart disease?
What are the basic mechanisms and potential early markers of radiation-induced heart disease?
This review outlines the molecular and metabolic mechanisms underlying radiation-induced heart disease to help identify potential targets for intervention and early markers of cardiac damage.
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May inform cardioprotective strategies in radiotherapy patients; leaves open prospective validation of targets and markers.
Slezák et al. (2017) conducted a review in Radiation-induced heart disease (RIHD). Radiation-induced heart disease is driven by reactive oxygen species, inflammation, and endothelial dysfunction, providing potential targets for intervention to modify radiation damage progression.
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