Key result
Cardiac nonmyocytes electrically couple with cardiomyocytes to influence cardiac electrophysiology and arrhythmogenesis.
Why the study?
Although cardiac action potential generation and propagation have traditionally been attributed exclusively to cardiomyocytes, nonmyocytes also form electrically conducting junctions and modulate electrical activity.
Design
Review
Authors
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Nonmyocyte-cardiomyocyte coupling may contribute to arrhythmias; leaves open clinical relevance and therapeutic targeting.
This review highlights the emerging understanding that nonmyocytes, including fibroblasts and macrophages, actively participate in cardiac electrical conduction and arrhythmogenesis.
Simón-Chica et al. (2023) conducted a review in Cardiac electrophysiology and arrhythmogenesis. Cardiac nonmyocytes, such as fibroblasts and macrophages, form functional electrical connections with cardiomyocytes in situ, contributing to cardiac electrophysiology and arrhythmogenesis.
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