Key result
Late gadolinium enhancement (LGE) angle strongly correlated with T2-weighted edema angle in reperfused acute myocardial infarction (r = 0.99, P < 0.01), allowing quantification of the area at risk.
Why the study?
Does the circumferential endocardial extent of myocardial infarction on LGE correlate with myocardial edema on T2W imaging in patients with reperfused AMI?
Observational (n=30)
Does the circumferential endocardial extent of myocardial infarction on LGE correlate with myocardial edema on T2W imaging in patients with reperfused AMI?
Effect estimate: r = 0.99
p-value: p=< 0.01
The strong correlation between the circumferential extent of edema and infarction on CMR suggests that T2-weighted imaging can be skipped to quantify the area at risk in reperfused AMI.
Suggests T2-weighted imaging may be omitted when assessing area at risk in reper.
T2 weighted (T2W) images on cardiovascular magnetic resonance (CMR) visualizes myocardial edema, which reflects the myocardial area at risk (AAR) in reperfused acute myocardial infarction (AMI). Late gadolinium enhancement (LGE) demonstrates myocardial infarction. LGE images cover the whole left ventricle, but T2W images are obtained from a few slices of the left ventricle due to the long sequence time, so the quantification of AAR of the entire left ventricle is difficult. We hypothesize that we can quantify AAR with only LGE images if there is a strong correlation between the circumferential endocardial extent of myocardial edema and infarction. Thirty patients with first AMI were enrolled. All patients underwent successfully reperfusion therapy and CMR was performed within the first week after the event. We measured the circumferential extent of edema and infarction on short-axis views (T2 angle and LGE angle), respectively. A total of 82 short-axis slices showed transmural edema on T2W images. Corresponding LGE images were analyzed for the circumferential extent of infarction. The median [interquartile range] of T2 angle and DE angle were 147° [116°-219°] and 134° [104°-200°] in patients with LAD culprit lesion, 91° [87°-101°] and 85° [80°-90°] in LCX, and 110° [94°-123°] and 104° [89°-118°] in RCA, respectively. T2 angle was well correlated with LGE angle (r = 0.99, P < 0.01). There is a strong correlation between the circumferential extent of edema and infarction in reperfused AMI. Thus, T2 weighted imaging can be skipped to quantify the amount of AAR.
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Ota et al. (2014) conducted an observational in Reperfused acute myocardial infarction (n=30). Late gadolinium enhancement (LGE) imaging vs. T2-weighted (T2W) imaging was evaluated on Correlation between circumferential extent of edema (T2 angle) and infarction (LGE angle) (r = 0.99, p=< 0.01). Late gadolinium enhancement (LGE) angle strongly correlated with T2-weighted edema angle in reperfused acute myocardial infarction (r = 0.99, P < 0.01), allowing quantification of the area at risk.
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