Why the study?
Does simulated obstructive apnoea increase sympathetic nerve activity more than simulated central apnoea in heart failure patients?
Population
14 human subjects (7 healthy subjects and 7 heart failure patients)
Comparison
15-s Mueller manoeuvres vs 15-s breath holds (simulated central apnoea)
Design
Other
Key result
In heart failure patients, simulated obstructive apnoea caused greater increases in sympathetic activity than simulated central apnoea (P<0.01), driven by an additional hypotensive effect.
Authors
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Supports greater sympathetic burden from obstructive apnoea in heart failure; leaves open whether targeted treatment improves outcomes.
Observational (n=14)
Does simulated obstructive apnoea increase sympathetic nerve activity more than simulated central apnoea in heart failure patients?
p-value: p=<0.01
Simulated obstructive sleep apnea elicits greater sympathetic activation than central apnea in heart failure patients due to its hypotensive effect, suggesting a mechanism for accelerated disease progression.
Bradley et al. (2003) conducted an observational in Heart failure (n=14). Simulated obstructive apnoeas (Mueller manoeuvres) vs. Simulated central apnoeas (breath holds) was evaluated on Muscle sympathetic nerve activity (p=<0.01). In heart failure patients, simulated obstructive apnoea caused greater increases in sympathetic activity than simulated central apnoea (P<0.01), driven by an additional hypotensive effect.