Why the study?
Does the Mueller maneuver alter left and right ventricular mechanics in healthy adults?
Population
24 healthy subjects (9 women; mean age, 30+/-6 years)
Comparison
Mueller maneuver to maintain a target… vs Baseline (resting state)
Design
Cross-sectional
Key result
The Mueller maneuver significantly decreased global left ventricular longitudinal strain in systole from -17.0% at baseline to -14.5% (P<0.0001) in healthy adults.
Authors
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Mueller maneuver may impair LV strain during apnea-like efforts; leaves open its contribution to OSA-related cardiomyopathy.
Observational (n=24)
Does the Mueller maneuver alter left and right ventricular mechanics in healthy adults?
Absolute Event Rate: -14.5% vs -17%
p-value: p=<0.0001
The Mueller maneuver significantly reduces left and right ventricular longitudinal deformation, suggesting that negative intrathoracic pressure during apnea alters myocardial mechanics.
Koshino et al. (2010) conducted an observational in Healthy adults (n=24). Mueller maneuver vs. baseline was evaluated on Global left ventricular longitudinal strain in systole (p=<0.0001). The Mueller maneuver significantly decreased global left ventricular longitudinal strain in systole from -17.0% at baseline to -14.5% (P<0.0001) in healthy adults.