Key result
Real-world observational studies require bias adjustment like propensity scores to confirm RCT treatment effectiveness.
Why the study?
Efficacy confirmed in randomized controlled trials is not necessarily confirmed in the real world, necessitating observational studies using large-scale real-world data to verify effectiveness.
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Design
Review
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Real-world data require bias adjustment before informing care; leaves open optimal methods to validate RCT findings observationally.
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Ryohei Yamamoto (2024) studied this question. Observational studies using real-world data must utilize bias adjustment techniques like propensity scores to accurately confirm the real-world effectiveness of treatments evaluated in RCTs.
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