In a study of 527 African Americans, insulin resistance was associated with both hypertension and plasma aldosterone in men, but not in women.
Observational (n=527)
No
Are there sex differences in the relationships between hypertension, insulin resistance, and aldosterone in African Americans?
Insulin resistance is associated with hypertension and plasma aldosterone in African American men but not women, potentially explaining sex disparities in cardiovascular risk.
African Americans, particularly men, have the highest morbidity and mortality rates from hypertension in the United States. The authors studied 527 African Americans in a general clinical research center to determine whether there are sex differences in the relationships between hypertension with insulin resistance (IR) and aldosterone, which are risk factors for cardiovascular disease. Measurements included ambulatory blood pressure (BP), anthropometric measures, plasma renin activity, plasma aldosterone (PA) concentration, and fasting serum lipids, glucose, and insulin. IR was estimated using the Homeostasis Model Assessment (HOMA) model. BP correlated with aldosterone in both sexes. However, both BP and PA correlated with IR in men, but not in women. Compared with men in the lower tertile of HOMA-IR, men in the upper tertile had higher mean systolic BP, a higher odds ratio of having hypertension, and higher levels of PA. The association of IR with both hypertension and PA in men, but not in women, may contribute to the high prevalence of cardiovascular disease in African American men.
Kidambi et al. (Sun,) conducted a observational in Hypertension (n=527). Insulin resistance (HOMA-IR) vs. Lower vs upper tertile of HOMA-IR / Men vs Women was evaluated on Correlation between blood pressure, plasma aldosterone, and insulin resistance. In a study of 527 African Americans, insulin resistance was associated with both hypertension and plasma aldosterone in men, but not in women.