Key result
Type 2 diabetic rats exhibited accelerated progression of heart failure 8 weeks post-myocardial infarction compared with nondiabetic rats, evidenced by enhanced LV remodeling and dysfunction.
Why the study?
Does type 2 diabetes accelerate heart failure progression following myocardial infarction in rats?
Population
Male nondiabetic Wistar-Kyoto (WKY) and type 2 diabetic Goto-Kakizaki (GK) rats
Comparison
Coronary artery ligation to induce myocardial… vs Sham surgery; and comparison between diabetic…
Design
Preclinical
Follow-up
8 and 20 weeks
Authors
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Hypothesis-generating for diabetes accelerating post-MI HF; leaves open human translation and requires clinical validation.
Does type 2 diabetes accelerate heart failure progression following myocardial infarction in rats?
Type 2 diabetes accelerates the progression of heart failure and adverse left ventricular remodeling following myocardial infarction in a rat model.
Chandler et al. (2007) studied Myocardial infarction and heart failure in type 2 diabetes. Coronary artery ligation (myocardial infarction) vs. Coronary artery ligation in nondiabetic rats and sham surgery was evaluated on Heart failure progression (LV remodeling and contractile dysfunction). Type 2 diabetic rats exhibited accelerated progression of heart failure 8 weeks post-myocardial infarction compared with nondiabetic rats, evidenced by enhanced LV remodeling and dysfunction.
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