Key result
Increased BP variability in T2D potentially links to higher mortality and CV risk despite inconclusive evidence.
Why the study?
Studies evaluating the prognostic importance of blood pressure variability for microvascular complications, extended MACE, and all-cause mortality in type 2 diabetes have shown inconclusive results.
Does blood pressure variability predict cardiovascular morbidity, mortality, and complications in patients with type 2 diabetes?
Does blood pressure variability predict cardiovascular morbidity, mortality, and complications in patients with type 2 diabetes?
While blood pressure variability is a potential therapeutic target for MACE in type 2 diabetes, current evidence is inconclusive and the primary goal remains controlling mean blood pressure levels.
Mean BP control remains priority in T2D; leaves open variability's independent prognostic value.
Increased blood pressure variability (BPV) has been found to significantly increase the risk of cardiovascular morbidity and mortality in the non-diabetic population. The prognostic importance of increased BPV for the development of micro- and macrovascular complications in type 2 diabetes has been investigated. Type 2 diabetes can increase BPV through different mechanisms, including increased arterial stiffness and autonomic dysfunction. Several studies in type 2 diabetic patients showed inconclusive results regarding all-cause mortality, microvascular complication, and extended major adverse cardiovascular events (MACE). However, some trials showed that BPV might be regarded as a potentially important therapeutic target in the management of type 2 diabetes regarding MACE. For now, the primary goal of antihypertensive treatment in patients with type 2 diabetes shall remain to controll mean blood pressure levels. However, when future studies show consistent results, BPV might be regarded as a therapeutic target in type 2 diabetic patients.
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Jeong et al. (2022) conducted a review in Type 2 diabetes mellitus. Blood pressure variability was evaluated. Increased blood pressure variability in patients with type 2 diabetes is potentially associated with higher risks of all-cause mortality and cardiovascular events, though current evidence remains inconclusive.
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