Key result
Age enhances the association between 24-h systolic blood pressure and target organ damage, with a 10 mmHg increase raising LVMI by 6.3 g/m in elderly vs 3.8 g/m in middle-aged individuals (P<0.01).
Why the study?
Does age modify the association between 24-h ambulatory blood pressure and target organ damage in healthy, nonmedicated individuals?
Cross-Sectional (n=1,408)
Does age modify the association between 24-h ambulatory blood pressure and target organ damage in healthy, nonmedicated individuals?
p-value: p=<0.01
Age significantly enhances the association between 24-h ambulatory blood pressure and measures of arterial stiffness, microvascular damage, and cardiac structure, suggesting older patients are more susceptible to BP-related target organ damage.
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Age may heighten ambulatory SBP effects on LVMI; leaves open causal implications and need for prospective validation before practice change.
Olesen et al. (2018) conducted a cross-sectional in Apparently healthy, nonmedicated individuals (n=1,408). 24-h ambulatory blood pressure measurements (24-h ABPM) vs. Age groups (middle-aged vs elderly) was evaluated on Target organ damage (left ventricular mass index, pulse wave velocity, urine albumin:creatinine ratio and carotid atherosclerotic plaques) (p=<0.01). Age enhances the association between 24-h systolic blood pressure and target organ damage, with a 10 mmHg increase raising LVMI by 6.3 g/m in elderly vs 3.8 g/m in middle-aged individuals (P<0.01).
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