Key result
Mixed hypertension was associated with higher left ventricular mass index (+4.31 g/m2), urinary albumin:creatinine ratio (+1.63 mg/mmol), and pulse wave velocity (+0.76 m/s) versus normotension.
Why the study?
Are 24-hour systolic and diastolic blood pressure levels and hypertension subtypes associated with target organ damage in untreated Chinese patients?
Population
1047 untreated Chinese subjects, mean age 50.6 years, 48.9% women.
Comparison
Hypertension subtypes and 24-hour… vs Normotension
Design
Cross-sectional
Authors
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May support risk stratification by hypertension subtype; leaves open whether 24-hour BP phenotypes guide therapy in untreated patients.
Cross-Sectional (n=1,047)
Are 24-hour systolic and diastolic blood pressure levels and hypertension subtypes associated with target organ damage in untreated Chinese patients?
24-hour systolic blood pressure and mixed hypertension are major determinants of target organ damage across ages, while diastolic blood pressure and isolated diastolic hypertension primarily relate to albuminuria in younger individuals.
Wei et al. (2013) conducted a cross-sectional in Hypertension (n=1,047). Hypertension subtypes (mixed systolic plus diastolic and isolated diastolic) vs. Normotension (<130/<80 mm Hg) was evaluated on Target organ damage (left ventricular mass index, urinary albumin:creatinine ratio, and aortic pulse wave velocity). Mixed hypertension was associated with higher left ventricular mass index (+4.31 g/m2), urinary albumin:creatinine ratio (+1.63 mg/mmol), and pulse wave velocity (+0.76 m/s) versus normotension.
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