Key result
Male sex was associated with greater ambulatory blood pressure values and target organ damage, including left ventricular mass and carotid intima-media thickness, compared to women of the same age.
Why the study?
How do age and sex affect ambulatory blood pressure measurements and target organ damage in patients with borderline hypertension?
Cross-Sectional (n=1,596)
How do age and sex affect ambulatory blood pressure measurements and target organ damage in patients with borderline hypertension?
Men with borderline hypertension exhibit higher ambulatory blood pressure and greater target organ damage compared to women of the same age.
Sex differences in ambulatory BP and target organ damage should not yet change practice; leaves open need for longitudinal validation in borderline hypertension.
OBJECTIVE: The objective of the present study was to investigate the effect of age and sex in the ambulatory blood pressure measurements, and target organ damage. METHODS: A total of 1596 patients (50.6% male and 49.4% female), aged 10-87 years, referred to our Hypertension Center for borderline hypertension, underwent 24-h ambulatory blood pressure monitoring, left ventricular echocardiography and measurement of intima-media thickness of carotid arteries. RESULTS: Adolescent girls had higher mean 24-h and clinic systolic and diastolic blood pressure values than adolescent boys. Men aged 20-60 years had higher mean 24-h and clinic systolic and diastolic blood pressure values than women of the same age. Men older than 60 years had higher mean 24-h systolic and diastolic blood pressure values than women of the same age, but women older than 60 years had higher clinic systolic and diastolic blood pressure values. White-coat effect increased with age in both sexes, but the magnitude of the white-coat effect was higher in women than in men at older ages. Men had higher left ventricular mass corrected for body surface area or height than women in all ages and significantly higher differences in ages between 30 and 80 years. In addition, men had greater carotid intima-media thickness than women in all ages and significantly higher differences in ages between 30 and 80 years. CONCLUSIONS: Men have greater ambulatory blood pressure values and target organ damage than women of the same age.
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Kotsis et al. (2006) conducted a cross-sectional in borderline hypertension (n=1,596). Male sex and increasing age vs. Female sex and younger age was evaluated on Ambulatory blood pressure measurements and target organ damage (left ventricular mass and carotid intima-media thickness). Male sex was associated with greater ambulatory blood pressure values and target organ damage, including left ventricular mass and carotid intima-media thickness, compared to women of the same age.
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