Key result
Acute hemorrhage in anesthetized pigs caused early return of pressure wave reflection from the abdominal vasculature, leading to systolic pressure augmentation in the ascending aorta.
Why the study?
Does hemorrhage alter wave-reflection-induced systolic pressure augmentation in anesthetized pigs?
RCT (n=25)
randomized
No
Does hemorrhage alter wave-reflection-induced systolic pressure augmentation in anesthetized pigs?
Hemorrhage-induced splanchnic vasoconstriction causes early return of pressure wave reflection from the abdominal vasculature, leading to systolic pressure augmentation in the ascending aorta.
Hypothesis-generating for aortic pressure changes in hemorrhage; human studies required before clinical relevance.
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Dark et al. (2006) conducted an RCT in acute hemorrhage (n=25). Hemorrhage vs. Surgical controls was evaluated on Wave-reflection-induced systolic pressure augmentation in the aorta. Acute hemorrhage in anesthetized pigs caused early return of pressure wave reflection from the abdominal vasculature, leading to systolic pressure augmentation in the ascending aorta.
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