Key result
Increases in overall open-loop gain and dead time of heart rate response after a mild hemorrhage were correlated with arterial pressure instability and oscillation in anesthetized cats.
In a feline model, marked increases in heart rate following mild hemorrhage serve as a predictor of arterial pressure oscillation and instability.
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Heart rate surges may flag pressure instability after mild hemorrhage in cats; leaves open human translation and clinical monitoring utility.
The stability of the arterial pressure control system after a mild hemorrhage (5 ml/kg body wt) was studied in 10 anesthetized cats by analyzing the responses of arterial pressure and of heart rate and the dead time (L) of heart rate response to a minute, rapid test hemorrhage (1 ml/kg body wt). The overall open-loop gain (H) of the arterial pressure control system was estimated from the ratio of arterial pressure fall immediately after the quick hemorrhage over the steady-state fall. Increases in H and L were correlated with the tendency of the arterial pressure control system to be unstable and oscillate. Oscillation in arterial pressure was always accompanied by a marked increase in heart rate (deltaHR), which represents an enhanced activity of the sympathetic nervous system and serves to restore arterial pressure toward the prehemorrhage level. The present study indicates that the magnitude of deltaHR also serves as a good predictor of arterial pressure oscillation.
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H. Hosomi (1978) studied Mild hemorrhage (n=10). Mild hemorrhage was evaluated on Stability of the arterial pressure control system (responses of arterial pressure, heart rate, dead time, overall open-loop gain). Increases in overall open-loop gain and dead time of heart rate response after a mild hemorrhage were correlated with arterial pressure instability and oscillation in anesthetized cats.
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