May 1, 1982Circulation ResearchOpen Access

Cardiac dynamics during hemorrhage. Relative unimportance of adrenergic inotropic responses.

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Why the study?

Does beta-adrenergic activation significantly contribute to cardiac contractility during acute hemorrhage in conscious dogs?

Population

Conscious dogs

Comparison

Acute hemorrhage with or without beta-adrenergic… vs Baseline and dogs without beta-adrenergic…

Design

Preclinical

Follow-up

1 hour

Authors

THThomas H. HintzeHeart Failure / Cardiomyopathy SVS. F. VatnerRutgers, The State University of New Jersey

Discussion

Member takes

Implication

May downplay beta-adrenergic support of contractility in acute hemorrhage; leaves open translation to human physiology.

Structured PICO

Does beta-adrenergic activation significantly contribute to cardiac contractility during acute hemorrhage in conscious dogs?

Population

Conscious dogs

Intervention

Acute hemorrhage (30 ml/kg over 1 hour or at 1 ml/sec) with or without beta-adrenergic receptor blockade

Comparator

Baseline (pre-hemorrhage) and dogs without beta-adrenergic receptor blockade

Outcome

Changes in cardiac dynamics including mean arterial pressure, LV pressures, LV diameters, LV dP/dt, LV dP/dt/P40, LV dP/dt/circ, and LV dD/dtsurrogate

In conscious dogs, sympathetic nervous system activation provides only minor contributions to cardiac contractility during acute hemorrhage.

Cite This Study

Hintze et al. (1982) studied this question.

synapsesocial.com/papers/6a902fde2a22b8e8a92da16f https://doi.org/10.1161/01.res.50.5.705

View Full Paper

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Cardiac dynamics during hemorrhage. Relative unimportance of adrenergic inotropic responses.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac dynamics during hemorrhage. Relative unimportance of adrenergic inotropic responses.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider