Key result
Cardiac resynchronization therapy reduces mortality and morbidity, and improves quality of life and functional class in patients with heart failure with reduced ejection fraction.
Why the study?
This study aimed to analyze the main indications for the use of CRT in HFrEF available in the literature.
Does cardiac resynchronization therapy improve mortality, morbidity, and quality of life in patients with heart failure with reduced ejection fraction?
Does cardiac resynchronization therapy improve mortality, morbidity, and quality of life in patients with heart failure with reduced ejection fraction?
This literature review reinforces that cardiac resynchronization therapy is an effective intervention for reducing mortality and improving quality of life in appropriately selected patients with HFrEF and widened QRS.
Introduction: cardiac resynchronization therapy (CRT) is a therapeutic modality for patients with heart failure (HF) refractory to optimized pharmacological treatment.Goal: This study aimed to analyze the main indications for the use of CRT in HFrEF available in the literature.Methods: This is a literature review in the following databases: New England Journal of Medicine, American Heart Association, SCIENSE, JACC.Articles in English during the period 2002 -2013 were selected.The Brazilian Guideline for Chronic and Acute Heart Failure was also consulted.Discussion: CRT has established itself as an important therapy in the treatment of HF, mainly in patients with NYHA functional class III and IV.Its effectiveness has been widely documented in several clinical trials, which have shown clinical benefits related to symptom improvement, reduced hospital admissions and improved survival.Conclusion : from the analysis of the studies presented in this literature review, it is possible to conclude that CRT, when well indicated, is capable of reducing mortality and morbidity, in addition to showing favorable impacts on improving the quality of life and, consequently, the functional class.
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Pereira et al. (2023) conducted a review in Heart Failure with Reduced Ejection Fraction (HFrEF). Cardiac Resynchronization Therapy (CRT) vs. Optimized clinical treatment or ICD alone was evaluated. Cardiac resynchronization therapy reduces mortality and morbidity, and improves quality of life and functional class in patients with heart failure with reduced ejection fraction.
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