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Diagnostic evaluation reveals postictal serum prolactin elevation differentiates epileptic seizures from pseudoseizures, indicating predictive value depends heavily on population prevalence.
Serum prolactin levels rise after generalized tonic-clonic and partial complex seizures, but not after pseudoepileptic seizures. The criteria for a significant elevation in serum prolactin vary with individual investigators. The prevalence of pseudoseizures in the population studied determines the predictive value of serum prolactin determinations. In populations where most patients have epilepsy, a rise in serum prolactin is highly predictive for true epilepsy, but no increase in serum prolactin is not predictive for pseudoseizures.
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Yerby et al. (1987) studied this question.
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