Key result
Losartan normalized blood pressure, insulin resistance, and norepinephrine-induced vasoconstriction in fructose-fed rats, but did not improve acetylcholine-induced relaxation.
Why the study?
Does losartan improve PVAT-derived vascular dysfunction in fructose-induced hypertensive rats?
Does losartan improve PVAT-derived vascular dysfunction in fructose-induced hypertensive rats?
Losartan partly improves PVAT-associated vascular regulation and normalizes blood pressure and insulin resistance in a rat model of metabolic syndrome.
Losartan warrants no change in metabolic hypertension care; extends animal data on partial PVAT effects but leaves human translation open.
Recent studies have shown the effect of perivascular adipose tissue (PVAT) on the regulation of vascular function; however, its role in the model of metabolic syndrome remains unclear. The aim of this study was to examine the effect of losartan on PVAT-derived vascular dysfunction in fructose-induced hypertensive rats. Rats were fed with either water, 10% fructose, or 10% fructose with 10mg/kg losartan for 8 weeks. In the isolated aorta with PVAT and endothelium, contraction induced by norepinephrine (NE) was more potent in fructose-fed rats compared to control rats. Losartan normalized blood pressure, insulin resistance, and NE-induced vasoconstriction in fructose-fed rats. In the aortic rings with/without endothelium and with/without PVAT, losartan could not improve the acetylcholine-induced relaxation in fructose-fed rats. The observation suggested that losartan partly improved the PVAT-associated vascular regulation in fructose-induced hypertensive rats.
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Huang et al. (2010) studied Fructose-induced hypertension. Losartan vs. Water or 10% fructose alone was evaluated on PVAT-derived vascular dysfunction (norepinephrine-induced vasoconstriction and acetylcholine-induced relaxation). Losartan normalized blood pressure, insulin resistance, and norepinephrine-induced vasoconstriction in fructose-fed rats, but did not improve acetylcholine-induced relaxation.
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