Why the study?
Does endothelium-dependent relaxation to noradrenaline and substance P vary across different large arteries in dogs?
Population
Ring preparations from the carotid, coronary, renal, mesenteric and femoral arteries of the dog
Comparison
Noradrenaline, UK14304, and Substance P vs Endothelium-denuded arteries, and comparison…
Design
Preclinical
Authors
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Endothelium-dependent noradrenaline relaxation varies by canine artery; leaves open translation to human coronary or peripheral vasomotor function.
Does endothelium-dependent relaxation to noradrenaline and substance P vary across different large arteries in dogs?
Endothelium-dependent relaxation mediated by alpha-2 adrenoceptors varies significantly across different vascular beds in dogs, being most prominent in coronary arteries.
Angus et al. (1986) studied this question.
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