What does this research mean for the field?

Fluoxetine treatment does not increase the risk of suicidal behavior in patients with affective disorders, and is instead associated with a nonsignificant reduction in risk despite these patients often having more severe illness prior to treatment. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1999American Journal of Psychiatry

Prospective Study of Fluoxetine Treatment and Suicidal Behavior in Affectively Ill Subjects

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Why the study?

Does fluoxetine increase the risk of suicidal behavior in patients with affective disorders?

Structured PICO

Does fluoxetine increase the risk of suicidal behavior in patients with affective disorders?

Population

643 subjects with affective disorders from the National Institute of Mental Health Collaborative Depression Study

Intervention

Fluoxetine

Comparator

No treatment or other somatic antidepressants

Outcome

Suicide attempts or completionssafety

Fluoxetine use in affectively ill patients is not associated with an increased risk of suicidal behavior, but rather a nonsignificant reduction.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Fluoxetine not linked to increased suicidal behavior; challenges speculation yet leaves open causal effects in affective disorders.

Cite This Study

Leon et al. (1999) studied this question.

synapsesocial.com/papers/6a127d67c031bb6829a6b6eb https://doi.org/10.1176/ajp.156.2.195

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Prospective Study of Fluoxetine Treatment and Suicidal Behavior in Affectively Ill Subjects

Structured PICO

Discussion

Implication

Cite This Study

Prospective Study of Fluoxetine Treatment and Suicidal Behavior in Affectively Ill Subjects

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider