Key result
Oral L-Arginine reduced foam cell development post surgical embolectomy compared to control (1.49 vs 13.38), though the difference was not statistically significant (p>0.05).
Why the study?
Fogarty balloon catheter vascular injury triggers endothelial dysfunction and foam cell development, but the effect of L-arginine on foam cell formation post-embolectomy required investigation.
Does oral L-Arginine reduce foam cell development post surgical embolectomy in a rabbit model?
RCT (n=16)
randomized
No
Does oral L-Arginine reduce foam cell development post surgical embolectomy in a rabbit model?
Absolute Event Rate: 1.49% vs 13.38%
p-value: p=>0.05
Oral L-Arginine did not significantly reduce foam cell development 28 days after surgical embolectomy in a rabbit model.
Does not support L-arginine to limit foam cells post-embolectomy; leaves open benefit in larger preclinical models.
Vascular injury caused by Fogarty balloon cathetering lead on endothelial dysfunction and trigger the development of foam cell, early atherosclerosis plaque. L-Arginine, as a nitric oxide precursor, has shown to decrease foam cell development. The aim of this study is to prove the effect of L-Arginine on decreasing the amount of foam cell post surgical embolectomy with Fogarty balloon catheter on iliac arteries of rabbit. Sixteen male rabbits were randomized divided into two group of treatment (n=8). After surgical embolectomy in right iliac artery has done, rabbits were fed standard ration (T0) and standard ration with oral L-Arginine (T1). At 28 days after surgical embolectomy, necropsy was done and foam cells were counted. Vascular injury by Fogarty balloon catheter resulted in the development of foam cells both in T0 (13.38 ±14.64) and T1(1.49 ± 1.20). Unpaired t test result showed not significant different (p0.05). The conclusion of this research is L-Arginine reduces the amount of foam cell post surgical embolectomy with Fogarty balloon catheter on iliac arteries of rabbit, however statistical test did not show any difference.
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Maulana et al. (2022) conducted an RCT in Post surgical embolectomy with Fogarty balloon catheter (n=16). Oral L-Arginine vs. Standard ration was evaluated on Amount of foam cells (p=>0.05). Oral L-Arginine reduced foam cell development post surgical embolectomy compared to control (1.49 vs 13.38), though the difference was not statistically significant (p>0.05).
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