Why the study?
Does L-arginine reduce iliac artery wall thickness in rabbits post-surgical embolectomy with Fogarty balloon catheter?
Does L-arginine reduce iliac artery wall thickness in rabbits post-surgical embolectomy with Fogarty balloon catheter?
Oral administration of L-arginine significantly reduces iliac artery wall and intimal thickness following Fogarty balloon catheter embolectomy in a rabbit model.
Reduces post-embolectomy intimal thickness in rabbits; hypothesis-generating for human restenosis prevention.
The effect of the chronic administration of L-arginine on iliac arteries thickness after surgical embolectomy using Fogarty balloon catheter were examined. Sixteen New Zealand White male rabbits underwent unilateral iliac artery surgical embolectomy using Fogarty balloon catheter. Then the animals were divided into two group of control (P0) fed with standard rabbit diet and treatment (P1) standard rabbit diet added with L-arginine in their drinking water 4 for weeks. The iliac arteries were harvested for histological slide preparation with routine method, observed under the microscope attached with Nikon camera and measured using NIS-Element BR application in 8 zones. Data were collected and analyzed by independent T-test. The result of the vessel thickness was significantly decreased on the P1 (234.1± 18.1 µm) than P0 (411.6 ± 191.7 µm). Furthermore, the thickness of intimal was significantly decrease in P1 (140.9± 27.0 µm) compared with P0 (304.3± 215.7 µm). As a result, there was no significant different on the thickness of medial between P1 (93.2± 15.7 µm) and P0 (107.3± 101.5 µm). The results demonstrate that L-arginine decreased iliac artery wall thickness after surgical embolectomy with Fogarty balloon catheter in rabbit.
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Puspitarani et al. (2017) studied this question.
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