October 1, 1989Neurology
Prediction of carotid stenosis progression by lipid and hematologic measurements
Key result
A combination of coronary artery disease, elevated LDL, and elevated fibrinogen predicted the progression of asymptomatic carotid stenosis with 88% accuracy.
Why the study?
Do lipid and hematologic measurements predict the progression of asymptomatic carotid stenosis?
Population
38 patients (19 men, 19 women) with asymptomatic carotid stenosis
Design
Cohort
Follow-up
up to 30 months
Authors
Discussion
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Member takes
Implication
May refine risk stratification for asymptomatic carotid stenosis; leaves open whether modifying LDL or fibrinogen alters progression.
Study Design
Type
Cohort (n=38)
Structured PICO
Do lipid and hematologic measurements predict the progression of asymptomatic carotid stenosis?
P
Population
38 patients (19 men, 19 women) with asymptomatic carotid stenosis
O
Outcome
Progression of carotid atherosclerosis (increase in mean percent stenosis ≥19% or increase in a single region ≥23% on B-mode carotid ultrasonography)surrogate
Elevated LDL, fibrinogen, and the presence of coronary artery disease can predict the progression of asymptomatic carotid stenosis with high accuracy.
Cite This Study
Grotta et al. (1989) conducted a cohort in Asymptomatic carotid stenosis (n=38). Elevated LDL, fibrinogen, and coronary artery disease vs. Normal levels / no coronary artery disease was evaluated on Progressing carotid atherosclerosis (increase in mean percent stenosis ≥19% or single region ≥23%). A combination of coronary artery disease, elevated LDL, and elevated fibrinogen predicted the progression of asymptomatic carotid stenosis with 88% accuracy.