Key result
Progressive carotid stenosis detected by ultrasound significantly increased the risk of major adverse cardiovascular events compared to nonprogressive disease (HR 2.01; 95% CI 1.48-2.67; P<0.001).
Why the study?
Does progressive carotid stenosis detected by duplex ultrasonography predict major adverse cardiovascular events in cardiovascular high-risk patients?
Population
1065 cardiovascular high-risk patients initially asymptomatic with respect to carotid disease
Comparison
Progressive carotid stenosis determined by… vs Nonprogressive carotid disease
Design
Cohort
Follow-up
median 3.2 years
Authors
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May enhance risk stratification in high-risk patients; hypothesis-generating pending prospective trials.
Cohort (n=1,065)
Does progressive carotid stenosis detected by duplex ultrasonography predict major adverse cardiovascular events in cardiovascular high-risk patients?
Hazard Ratio: 2.01 (95% CI 1.48–2.67)
p-value: p=<0.001
Progression of carotid stenosis over 6-9 months detected by ultrasound is a strong predictor of midterm adverse cardiovascular events in high-risk patients.
Sabeti et al. (2007) conducted a cohort in Cardiovascular high-risk patients asymptomatic for carotid disease (n=1,065). Progressive carotid stenosis vs. Nonprogressive carotid disease was evaluated on Major adverse cardiovascular events (composite MACEs: myocardial infarction, percutaneous coronary or peripheral interventions, coronary or vascular surgery, amputation, stroke, and all-cause mortality) (HR 2.01, 95% CI 1.48 to 2.67, p=<0.001). Progressive carotid stenosis detected by ultrasound significantly increased the risk of major adverse cardiovascular events compared to nonprogressive disease (HR 2.01; 95% CI 1.48-2.67; P<0.001).
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