Key result
Progression of moderate asymptomatic carotid stenosis is linked to a ~21-fold higher vascular risk.
Why the study?
Ultrasound monitoring of moderate asymptomatic carotid stenosis may help identify subjects at high risk for vascular events.
Does 1-year progression of moderate asymptomatic carotid stenosis predict the risk of vascular events in subjects with unilateral asymptomatic carotid stenosis of 50% to 69%?
Population
523 subjects with unilateral asymptomatic carotid stenosis of 50% to 69%
Comparison
Progression of carotid stenosis within 12 months vs no progression
Design
Prospective cohort study
Follow-up
Median 42 months
Authors
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Progression of moderate asymptomatic carotid stenosis was associated with high vascular event risk; leaves open whether serial ultrasound monitoring improves risk stratification or outcomes.
Cohort (n=523)
Does 1-year progression of moderate asymptomatic carotid stenosis predict the risk of vascular events in subjects with unilateral asymptomatic carotid stenosis of 50% to 69%?
Hazard Ratio: 21.57 (95% CI 11.81–39.39)
Absolute Event Rate: 53.7% vs 3.3%
p-value: p=<0.001
One-year progression of moderate asymptomatic carotid stenosis strongly predicts a higher risk of vascular events, including ipsilateral stroke.
Balestrini et al. (2013) conducted a cohort in moderate asymptomatic carotid stenosis (n=523). Carotid stenosis progression vs. No carotid stenosis progression was evaluated on any stroke and transient ischemic attack, myocardial infarction, and death (HR 21.57, 95% CI 11.81-39.39, p=<0.001). One-year progression of moderate asymptomatic carotid stenosis was associated with a significantly higher risk of vascular events (HR 21.57; 95% CI 11.81-39.39; P<0.001).
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