Key result
Gene products such as the MyoD family regulate developmental cell fate by directing the commitment of multipotential stem cells to specific lineages.
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Leaves open therapeutic targeting of cell fate regulators in regenerative medicine; extends invertebrate findings to mammalian systems.
The establishment of specialized cell types during development involves commitment of multipotential stem cells to specific lineages and subsequent expression of distinct sets of cell type-specific genes. Several gene products that regulate cell fate have been identified in DrosophiIa and Caenorhabditis elegans, however, the 10.1101/gad.4.9.
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Eric N. Olson (1990) studied this question. Gene products such as the MyoD family regulate developmental cell fate by directing the commitment of multipotential stem cells to specific lineages.
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