Key result
One night of CPAP therapy prevented significant changes in nLF/nHF seen in the control group (0.72 vs 1.11, P=0.006) and significantly increased sMSE, reducing sympathovagal imbalance.
Why the study?
Does one night of CPAP therapy improve heart rate variability and physiological complexity in patients with moderate to severe untreated OSA?
Observational (n=35)
Does one night of CPAP therapy improve heart rate variability and physiological complexity in patients with moderate to severe untreated OSA?
p-value: p=0.006
A single night of CPAP therapy in patients with moderate to severe OSA may reduce sympathovagal imbalance and increase physiological complexity.
One night of CPAP may reduce sympathovagal imbalance in moderate-severe OSA; leaves open effects on clinical outcomes.
Studies regarding the effects of short-term continuous positive airway pressure (CPAP) therapy are not sufficient. A total of 35 patients with moderate to severe untreated OSA were divided into 2 groups. Group 1 comprised 22 patients who underwent polysomnography (PSG) for one night, and Group 2 comprised 13 patients who received PSG combined with CPAP therapy. To evaluate the influence of receiving CPAP therapy for one night, we measured 5 min wrist pulse signals before and after the experiment to assess heart rate variability, as well as novel short time multiscale entropy (sMSE) indicator that examines complexity in physiological signals. The results show that the participants in Group 1 exhibited significant changes in normalized low-frequency power/normalized high-frequency power (nLF/nHF) (0.72 ± 0.09 versus 1.11 ± 0.11, P = 0.006) values before and after the PSG study. By contrast, the participants in Group 2 showed no significant changes in the 3 indicators. Regarding the sMSE indicator, Group 2 patients exhibited significant increases in the sMSE. CPAP therapy administered for one night can reduce the sympathovagal imbalance in patients with moderate to severe untreated OSA and increase the complexity of the patient's physiological system, thereby reflecting their overall improved health.
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Wu et al. (2014) conducted an observational in moderate to severe untreated OSA (n=35). CPAP therapy vs. Polysomnography (PSG) without CPAP was evaluated on Heart rate variability (nLF/nHF) and short time multiscale entropy (sMSE) (p=0.006). One night of CPAP therapy prevented significant changes in nLF/nHF seen in the control group (0.72 vs 1.11, P=0.006) and significantly increased sMSE, reducing sympathovagal imbalance.
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