Key result
Radical left ventricular aneurysm resection in 22 patients with global EF ≤20% yielded 20 survivors who showed significant improvement of global systolic LV function and regional ejection fraction.
Why the study?
Does radical LVA resection improve LV function in patients with postinfarction anterior-apical LVA and global ejection fraction ≤20%?
Observational (n=22)
Does radical LVA resection improve LV function in patients with postinfarction anterior-apical LVA and global ejection fraction ≤20%?
Radical left ventricular aneurysm resection can be performed with acceptable risk and significantly improves global and regional LV function in patients with postinfarction anterior-apical LVA and severely depressed LVEF (≤20%).
Answers are grounded in this paper and cite their sources.
May support resection in selected post-MI LVA with EF≤20%; hypothesis-generating case series, needs controlled trials.
Physical performance and left ventricular (LV) function in the resting state were assessed in 22 patients with postinfarction anterior-apical left ventricular aneurysm (LVA) and global ejection fraction less than or equal to 20% who subsequently underwent radical LVA resection. The basic findings in the 20 survivors of surgery were significant improvement of global systolic LV function and more or less complete recovery of regional ejection fraction in the predominantly viable low and high lateral LV wall. This improvement was evident in patients with concomitant bypass grafting as well as in those with isolated and ungraftable lesions of the left anterior descending (LAD) coronary artery. We conclude that postinfarction anterior-apical LVA in a poorly functioning LV is suitable for surgical treatment, which can be accomplished with acceptable risk. All graftable stenotic major coronary arteries should be bypassed, in addition to the LVA resection, but a minority of patients with isolated, ungraftable LAD disease are likely to benefit from aneurysmectomy alone.
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Oxelbark et al. (1992) conducted an observational in Postinfarction anterior-apical left ventricular aneurysm with poor LV function (n=22). Radical left ventricular aneurysm (LVA) resection was evaluated on Physical performance and left ventricular (LV) function in the resting state. Radical left ventricular aneurysm resection in 22 patients with global EF ≤20% yielded 20 survivors who showed significant improvement of global systolic LV function and regional ejection fraction.
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