What question did this study set out to answer?

To characterize the novel, water-soluble, slow-releasing hydrogen sulfide donor GYY4137 and evaluate its cardiovascular actions in preclinical models.

April 29, 2008CirculationOpen Access

Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137)

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Authors

LLLing LiMinistry of Education of the People's Republic of China MWMatthew WhitemanUniversity of Exeter YGYanyi GuanKing's College London

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Implication

Experimental study demonstrates vasodilator and antihypertensive effects of slow-releasing GYY4137 in rat models, indicating therapeutic potential for cardiovascular disease.

Key Points

To characterize the novel, water-soluble, slow-releasing hydrogen sulfide donor GYY4137 and evaluate its cardiovascular actions in preclinical models.
Assessed acute vasorelaxant effects in rat aortic rings and perfused rat kidney in vitro, as well as in anesthetized rats in vivo.
Measured blood pressure responses during acute N(G)-nitro-L-arginine methyl ester-evoked hypertension and after 14-day chronic administration in spontaneously hypertensive rats using tail-cuff plethysmography.
GYY4137 slowly released hydrogen sulfide in aqueous solution and in vivo, causing sustained relaxation of aortic rings and dilation of renal vasculature via smooth muscle K(ATP) channel activation.
GYY4137 did not alter heart rate or force of myocardial contraction in vitro, but significantly lowered blood pressure in acute and 14-day chronic hypertensive rat models.

Cite This Study

Li et al. (2008) studied this question.

synapsesocial.com/papers/6a129ce0e407b26696354443 https://doi.org/10.1161/circulationaha.107.753467

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Implication

Experimental study demonstrates vasodilator and antihypertensive effects of slow-releasing GYY4137 in rat models, indicating therapeutic potential for cardiovascular disease.

Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137)

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Implication

Key Points

Cite This Study

Characterization of a Novel, Water-Soluble Hydrogen Sulfide–Releasing Molecule (GYY4137)

Discussion

Member takes

Implication

Key Points

Cite This Study

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