January 1, 1978Cancer

Neuroblastoma in the adult. Effective combination chemotherapy

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Why the study?

Does combination chemotherapy (CYVADIC or CYVADACT) induce remission and prolong survival in adults with widespread neuroblastoma?

Population

6 adult patients (>16 years of age) with widespread neuroblastoma diagnosed between 1974 and 1976.

Design

Case_series

Follow-up

median >11 months

Authors

GDGary M. DosikJohnson & Johnson (United States)VRVictorio RodriguezBrooke Army Medical Center RBRobert S. BenjaminCardio-Oncology

Discussion

Member takes

Implication

May support remission in rare adult neuroblastoma cases; hypothesis-generating and requires prospective trials.

Structured PICO

Does combination chemotherapy (CYVADIC or CYVADACT) induce remission and prolong survival in adults with widespread neuroblastoma?

Population

6 adult patients (>16 years of age) with widespread neuroblastoma diagnosed between 1974 and 1976.

Intervention

Combination chemotherapy with cyclophosphamide, vincristine, adriamycin and dimethyl triazeno imidazole carboxamide (CYVADIC) (n=5) or with actinomycin D substituted for dimethyl triazeno imidazole carboxamide (CYVADACT) (n=1).

Outcome

Response rate (complete and partial) and median duration of survivalhard clinical

Combination chemotherapy (CYVADIC or CYVADACT) is effective in achieving remission and prolonging survival in adults with widespread neuroblastoma.

Cite This Study

Dosik et al. (1978) studied this question.

synapsesocial.com/papers/6a129ec14891eb3ecca3ff61 https://doi.org/10.1002/1097-0142(197801)41:1<56::aid-cncr2820410110>3.0.co;2-2

View Full Paper

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Neuroblastoma in the adult. Effective combination chemotherapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Neuroblastoma in the adult. Effective combination chemotherapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider