Key result
Free-breathing compressed sensing cine MRI cuts acquisition time ~93% while yielding similar global strain rates.
Why the study?
It was unclear whether cardiac MRI feature-tracking strain measurements could be reliably derived from free-breathing compressed sensing bSSFP imaging.
Does free-breathing compressed sensing cine cardiac MRI provide reliable left ventricular strain measurements and image quality compared to conventional breath-holding cine MRI in children?
Observational (n=57)
Does free-breathing compressed sensing cine cardiac MRI provide reliable left ventricular strain measurements and image quality compared to conventional breath-holding cine MRI in children?
Free-breathing compressed sensing cine MRI significantly reduces acquisition time while providing comparable left ventricular strain measurements and image quality to conventional breath-holding MRI in children.
May shorten pediatric cardiac MRI exams; leaves open need for prospective validation before routine strain assessment.
BACKGROUND: Cardiac MRI feature-tracking (FT) with breath-holding (BH) cine balanced steady state free precession (bSSFP) imaging is well established. It is unclear whether FT-strain measurements can be reliably derived from free-breathing (FB) compressed sensing (CS) bSSFP imaging. PURPOSE: To compare left ventricular (LV) strain analysis and image quality of an FB CS bSSFP cine sequence with that of a conventional BH bSSFP sequence in children. STUDY TYPE: Prospective. SUBJECTS: 40 children able to perform BHs (cohort 1 [12.1 ± 2.2 years]) and 17 children unable to perform BHs (cohort 2 [5.2 ± 1.8 years]). FIELD STRENGTH/SEQUENCE: 3T, bSSFP sequence with and without CS. ASSESSMENT: Acquisition times and image quality were assessed. LV myocardial deformation parameters were compared between BH cine and FB CS cine studies in cohort 1. Strain indices and image quality of FB CS cine studies were also assessed in cohort 2. Intraobserver and interobserver variability of strain parameters was determined. STATISTICAL TESTS: Paired t-test, Wilcoxon signed-rank test, intraclass correlation coefficient (ICC), and Bland-Altman analysis. A P-value <0.05 was considered statistically significant. RESULTS: In cohort 1, the mean acquisition time of the FB CS cine study was significantly lower than for conventional BH cine study (15.6 s vs. 209.4 s). No significant difference were found in global circumferential strain rate (P = 0.089), global longitudinal strain rate (P = 0.366) and EuroCMR image quality scores (P = 0.128) between BH and FB sequences in cohort 1. The overall image quality score of FB CS cine in cohort 2 was 3.5 ± 0.5 with acquisition time of 14.7 ± 2.1 s. Interobserver and intraobserver variabilities were good to excellent (ICC = 0.810 to 0.943). DATA CONCLUSION: FB CS cine imaging may be a promising alternative technique for strain assessment in pediatric patients with poor BH ability. LEVEL OF EVIDENCE: 1 TECHNICAL EFFICACY: Stage 1.
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Xu et al. (2023) conducted an observational in Pediatric patients (n=57). Free-breathing compressed sensing bSSFP cine sequence vs. Conventional breath-holding bSSFP sequence was evaluated on Global circumferential strain rate, global longitudinal strain rate, and EuroCMR image quality scores (p=0.089, 0.366, 0.128). Free-breathing compressed sensing cine MRI significantly reduced acquisition time (15.6s vs 209.4s) while yielding similar global circumferential (P=0.089) and longitudinal (P=0.366) strain rates.
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