Key result
Dietary omega-3 fatty acids significantly increased the frequency of pro-arrhythmic diastolic Ca2+ waves from 0.07 to 0.21 per second in ventricular myocytes from post-myocardial infarction dogs.
Why the study?
Does dietary n-3 PUFA alter the vulnerability of ventricular myocytes to cellular arrhythmia by stabilizing intracellular Ca2+ cycling in a post-MI canine model?
Population
Canine model of post-myocardial infarction sudden cardiac death; heartworm-free mixed breed dogs stratified…
Comparison
Dietary omega-3 polyunsaturated fatty acids 1-4… vs Placebo administered orally for 3 months.
Design
Preclinical, Randomly assigned to placebo or n-3 PUFA groups
Follow-up
3 months
Authors
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Challenges presumed anti-arrhythmic benefits of omega-3 post-MI; leaves open translation to human arrhythmia risk.
Does dietary n-3 PUFA alter the vulnerability of ventricular myocytes to cellular arrhythmia by stabilizing intracellular Ca2+ cycling in a post-MI canine model?
Absolute Event Rate: 0.21% vs 0.07%
p-value: p=0.014
Dietary n-3 PUFAs do not alleviate intracellular Ca2+ cycling remodeling in post-MI VF+ hearts and actually increase vulnerability to cellular arrhythmia in post-MI VF- hearts by destabilizing intracellular Ca2+ handling.
Belevych et al. (2013) studied Post-myocardial infarction (canine model) (n=62). Dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) vs. Placebo (1 g/day corn oil) was evaluated on Frequency of diastolic Ca2+ waves (DCWs) per second in VF- myocytes (p=0.014). Dietary omega-3 fatty acids significantly increased the frequency of pro-arrhythmic diastolic Ca2+ waves from 0.07 to 0.21 per second in ventricular myocytes from post-myocardial infarction dogs.
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