Key result
Dietary n-3 PUFAs failed to prevent ischemia-induced arrhythmias in VF+ dogs (24% vs 27% for placebo; P=0.5646) and increased VT/VF susceptibility in VF- dogs (33% vs 0%; P=0.0442).
Why the study?
Does n-3 PUFA prevent ischemia-induced ventricular fibrillation in a canine model of sudden cardiac death?
Population
83 dogs
Comparison
n-3 PUFA for 3 months vs Placebo (1 g/d, corn oil) for 3 months
Design
Preclinical, Randomly assigned
Follow-up
3 months
Authors
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No antiarrhythmic benefit and possible proarrhythmic effect in canine VF model; leaves open n-3 PUFA role in human sudden death prevention.
RCT (n=83)
randomly assigned
Does n-3 PUFA prevent ischemia-induced ventricular fibrillation in a canine model of sudden cardiac death?
Absolute Event Rate: 24% vs 27%
p-value: p=0.5646
In a canine model, dietary n-3 PUFAs did not prevent ischemia-induced VF and paradoxically increased arrhythmia susceptibility in noninfarcted and low-risk post-MI dogs.
Billman et al. (2012) conducted an RCT in healed myocardial infarction (n=83). n-3 PUFA vs. placebo (1 g/d, corn oil) was evaluated on prevention of arrhythmias in VF+ dogs (p=0.5646). Dietary n-3 PUFAs failed to prevent ischemia-induced arrhythmias in VF+ dogs (24% vs 27% for placebo; P=0.5646) and increased VT/VF susceptibility in VF- dogs (33% vs 0%; P=0.0442).
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