Key result
ADD1 Gly460Trp polymorphism predicts arterial hypertension development in the Ukrainian population.
Why the study?
Alpha-adducin may be a potential marker for salt-sensitive arterial hypertension, prompting investigation into the association between the ADD1 Gly460Trp-polymorphism and hypertension development risk in the Ukrainian population.
Is the ADD1 Gly460Trp-polymorphism associated with the development of arterial hypertension in the Ukrainian population?
Case-Control (n=232)
Is the ADD1 Gly460Trp-polymorphism associated with the development of arterial hypertension in the Ukrainian population?
The ADD1 Gly460Trp-polymorphism may serve as a genetic marker for the risk of developing arterial hypertension in the Ukrainian population.
Answers are grounded in this paper and cite their sources.
May inform targeted screening in Ukrainians; leaves open prospective validation before clinical use.
Arterial hypertension (AH) belongs to the diseases with genetic predisposition that determines the necessity of research on the genetic component’s influence on this disease development. It is suggested that one of the salt-sensitive arterial hypertension potential markers may be the alpha-adducin gene because its protein product is involved in the ion transport regulation in the renal epithelium. Thus, the aim of the study was to investigate the association between ADD1 Gly460Trp-polymorphism and the AH development risk among patients with different risk factors in the Ukrainian population. The study included 232 Ukrainians: 120 patients with diagnosed arterial hypertension and 112 practically healthy individuals. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was used for ADD1 Gly460Trp-polymorphism genotyping. The ADD1 Gly460Trp-polymorphic locus is an important predictor of arterial hypertension development in the Ukrainian population, but other nongenetic factors should be considered in further studies.
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Yermolenko et al. (2021) conducted a case-control in Arterial hypertension (n=232). ADD1 Gly460Trp-polymorphism vs. Practically healthy individuals was evaluated on Arterial hypertension development. The ADD1 Gly460Trp-polymorphic locus is an important predictor of arterial hypertension development in the Ukrainian population.
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