Key result
Post-mortem analysis of over 3,000 young subjects confirmed that atherosclerosis originates in childhood, progresses in young adulthood, and is strongly influenced by cardiovascular risk factors.
Population
Over 3,000 subjects age 15 to 34 who died of external causes between 1987 and 1994
Design
Cross-sectional
Authors
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Supports early pediatric risk assessment; extends observational data on childhood origins but leaves practice change open.
Observational (n=3,000)
Yes
Atherosclerosis begins in childhood and its progression is strongly influenced by traditional cardiovascular risk factors, highlighting the critical need for primary prevention starting in early life.
Zieske et al. (2002) conducted an observational in Atherosclerosis (n=3,000). Post-mortem analysis of over 3,000 young subjects confirmed that atherosclerosis originates in childhood, progresses in young adulthood, and is strongly influenced by cardiovascular risk factors.
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